Disclaimer: This Guidelines supplement has been developed in partnership with Novartis. Novartis suggested the topic and authors, commented on the author briefs, and commissioned the production of the supplement. The content has also been checked to ensure its compliance with appropriate regulations. Novartis has paid the authors’ honoraria. The views and opinions expressed are not necessarily those of Novartis, or of Guidelines, its publisher, advisers, or advertisers. No part of this publication may be reproduced in any form without the permission of the publisher. Prescribing information can be found on the back cover.