Serum vitamin D may be linked to mortality in patients with existing CVD, researchers from Tongji Medical College have found

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Serum vitamin D may be linked to mortality in patients with existing cardiovascular disease (CVD), according to a study published in Frontiers in Nutrition.

According to the findings of the study, based on data including 37,079 patients with CVD (age 40–69 years) from the UK Biobank (2006–2010), approximately 60% of patients with CVD had vitamin D deficiency (less than 0 nmol/l). Elevated serum 25-hydroxyvitamin D (25[OH]D) levels were also independently associated with a lower risk of all-cause and cause-specific mortality in a non-linear and dose–response manner in patients with established CVD.

Key results

  • Of 37,079 patients with CVD, 21,331 (57.5%) had vitamin D deficiency (that is, 25[OH]D, less than 0 nmol/l)
  • During a median follow up of 11.7 years, 6319 total deaths occurred, including 2161 deaths from CVD, 2230 deaths from cancer, 623 deaths from respiratory diseases, and 1305 deaths from other causes
  • In patients with vitamin D deficiency (serum 25[OH]D, less than 0 nmol/l), per 10 nmol/l increase in serum 25(OH)D levels was associated with a lower risk of mortality from (adjusted hazard ratio; 95% confidence interval):
    • all-cause (0.88; 0.85–0.90)
    • CVD (0.91; 0.86–0.95)
    • cancer (0.90; 0.86–0.95)
    • respiratory diseases (0.81; 0.74–0.90), and
    • other causes (0.81; 0.76–0.87)
  • A non-linear inverse association was seen between serum 25(OH)D levels and mortality from all cause , cancer, respiratory diseases, and other causes (Pnon-linearity less than 0.01)
  • A linear inverse association was seen between serum 25(OH)D levels and CVD mortality (Pnon-linearity equal to 0.074).

Implications

These findings suggest that patients with vitamin D deficiency may benefit more from an increase in serum 25(OH)D levels than those with CVD and serum 25(OH)D levels of 0 nmol/l or greater.

This article originally appeared onUnivadis,part of the Medscape Professional Network.

You can also find our clinical summaries relating to CVD here.

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