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This section is part 6 of the PHE pneumococcal guideline summary.

Contents included in this summary



Anyone can report a suspected adverse reaction to the Medical and Healthcare products Regulatory Agency (MHRA) using the Yellow Card reporting scheme (http://yellowcard.mhra.gov.uk/).

The safety of the vaccine was assessed in controlled clinical studies and the safety profile of Prevenar13® was similar to Prevenar®. For Prevenar13®, the most commonly reported adverse reactions in children 6 weeks to 5 years of age were vaccination-site reactions, fever, irritability, decreased appetite, and increased and/or decreased sleep. Reports of all adverse reactions can be found in the summary of product characteristics for Prevenar 13® available at https://www.medicines.org.uk.


Mild soreness and induration at the site of injection lasting one to three days and, less commonly, a low grade fever may occur. More severe systemic reactions are infrequent. In general, local and systemic reactions are more common in people with higher concentrations of antibodies to pneumococcal polysaccharides.

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full guideline available from…


Public Health England. Immunisation against infectious disease (Green Book). London: Public Health England, 2018.  

Contains public sector information licensed under the Open Government Licence v3.0.

First included: May 2019.