Evidence-based guidelines for treating depressive disorders with antidepressants

British Association for Psychopharmacology


Depression is a common, recurrent disorder, about twice as common in women as men. It is one of the major causes of morbidity worldwide and is associated with increased mortality. Depression is commonly associated with other psychiatric disorders and increased rates are seen in medical illness. Treatment of major depression with antidepressants in primary care should ideally be in the context of case management, or collaborative care to improve outcomes. This should include a scheduled follow-up, an effective strategy to enhance adherence to medication, and access to a mental health specialist when required. This Guidelines summary provides updated recommendations on optimal prescribing, managing older people and adolescents with depression, and management of potential long-term side-effects.

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