A study found oral supplementation with urolithin A resulted in a significant improvement in muscle endurance

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According to an article published in JAMA Network Open, oral supplementation with urolithin A in older adults may have a beneficial effect on muscle endurance and biomarkers of mitochondrial health, highlighting its potential role in healthy ageing.

The analysis included 66 participants who were randomised to receive daily oral supplementation with either 1000 mg urolithin A (n=33) or placebo (n=33) for 4 months. Muscle fatigue tests and plasma analysis of biomarkers were assessed at baseline, 2 months, and 4 months. The primary endpoint was change from baseline in the 6-minute walk distance and change in maximal adenosine triphosphate production in the hand skeletal muscle from baseline to 4 months.

The mean change in the 6-minute walk distance was 60.8 metres among participants in the urolithin A group and 42.5 metres in the placebo group, which was not significant. However, the authors noted that both groups demonstrated significant improvements from baseline, suggesting that participation in the study motivated an increase in physical activity.

Supplementation with urolithin A resulted in a significant improvement in muscle endurance (number of muscle contractions until fatigue) compared with those who used placebo. Plasma levels of several biomarkers decreased after urolithin A supplementation, revealing an improvement in mitochondrial health.

This article originally appeared on Univadis, part of the Medscape Professional Network.

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