Disclaimer: Information for healthcare professionals only. This supplement has been commissioned by Norgine Pharmaceuticals Limited. Norgine Pharmaceuticals Limited was able to suggest relevant experts to Chair the group, with final decisions on the remaining group members resting with the Chair and Guidelines. Norgine Pharmaceuticals Limited has reviewed the supplement for technical and scientific accuracy, and to ensure its compliance with appropriate regulations. Final editorial control has remained with the contributors and Guidelines. The views and opinions of the contributors expressed in this document are not necessarily those of Norgine Pharmaceuticals Limited, or of Guidelines, its publishers, advisers, or advertisers.