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E45 Cream concise consultation card - digital

This concise consultation card was developed by Guidelines for Pharmacy in partnership with RB UK. 

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Download a PDF of this concise consultation card here

Dry skin conditions can cause a variety of unpleasant symptoms such as itching, redness, and inflammation.1 Your advice can help sufferers find relief and feel more in control.

This Guidelines for Pharmacy card summarises key professional guidance to help you advise customers and make confident recommendations.

What the guidelines say

“Emollient creams are vital in helping to manage dry skin conditions – NICE2

“Emollients should form the basis of atopic eczema management and should always be used, even when the atopic eczema is clear – NICE2

“Replacement of soaps and detergents with emollients is useful even if they are not the cause of the dematitis – British Associated of Dermatologists3

“Advise the person to apply the emollient liberally as often as it is needed, and to use around 500 g in a week – NICE4

Advice and discussion points 

Recommend emollients as first-line treatment for many different dry skin conditions.1,2

Explain how to apply emollients, including how to smooth emollients onto the skin rather than rubbing them in.2

Advise customers to try to identify potential trigger factors such as soaps, detergents, skin infections, or allergens.2

Refer to GP if symptoms do not get better, keep coming back, or are really affecting the patient’s quality of life.5


[A] For verification, please contact PO Box 4044, Slough SL1 0NS

What the studies show:

  • Applying E45 Cream 3 times a day for 12 weeks significantly reduces the severity of symptoms in children with eczema[B],6
  • At the beginning of treatment, there is a positive correlation between the control of eczema and the quantity of emollient used7
  • Healthcare professional advice can reduce eczema symptom severity by up to 89%.[C],7

[B] Based on an education support programme (ESP) involving 136 British children with atopic eczema for 12 weeks, 2013.
[C] Based on a nurse intervention study on 51 children with atopic eczema for one year, 2003.

Key facts: 

E45 Cream

  • E45 Cream is licensed for the treatment of:8
    • Dry, flaky skin
    • Eczema
    • Ichthyosis
    • Itchy skin
    • Dermatitis
    • Dry psoriasis[D]
    • Sunburn
    • Chapped skin
  • E45 Cream can be used up to 3 times a day.8

[D] For certain dry cases of psoriasis.


  1. Guenther L et al. J Cutan Med Surg 2012; 16: 23–31.
  2. NICE. Atopic eczema in under 12s: diagnosis and management. Clinical guideline 57. NICE, 2007. Available at: www.nice.org.uk/cg57.
  3. Johnson GA et al. Br J Dermatol 2017; 176: 317–332.
  4. NICE. CKS: Itch – widespread. NICE, 2016. Available at: https://cks.nice.org.uk/topics/itch-widespread/
  5. NHS. Itchy skin.www.nhs.uk/conditions/itchy-skin/ (Accessed 16 March 2021)
  6. Mason JM et al. BMC Dermatol 2013; 13: 7. 
  7. Cork MJ et al. Br J Dermatol 2003; 149: 582–589.
  8. E45 Cream. SPC. Accessed Jan 2021. www.medicines.org.uk/emc/product/6586

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse events should also be reported to Reckitt Benckiser Healthcare (UK) Ltd on: 0333 200 5345 


Date of preparation: March 2021