Crohn’s disease: management

National Institute for Health and Care Excellence


Crohn's disease is a chronic inflammatory disease that mainly affects the gastrointestinal tract. It is estimated that 115,000 people in the UK have Crohn's disease. Management of this condition involves drug therapy, nutritional interventions, smoking cessation and, in severe or chronic active disease, surgery. The aims of drug treatment are to reduce symptoms, promote mucosal healing, and maintain or improve quality of life, while minimising toxicity related to drugs over both the short‑ and long‑term. Treatment options include glucocorticosteroids, 5‑aminosalicylate (5‑ASA) treatment, antibiotics, immunosuppressants, and tumour necrosis factor (TNF)‑alfa inhibitors.

This updated Guidelines summary includes recommendations on patient information and support, inducing remission and maintaining remission.


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