Hormone replacement therapy

Menopause Matters

Principles of hormone replacement therapy

Indications and contraindications for HRT

  • Indications:
    • relief of menopausal symptoms (short-term)
    • prevention/treatment of osteoporosis (long-term)
    • premature ovarian failure
  • Contraindications:
    • pregnancy
    • undiagnosed abnormal vaginal bleeding
    • active thromboembolic disorder or acute-phase myocardial infarction
    • suspected or active breast or endometrial cancer
    • active liver disease with abnormal liver function tests
    • porphyria cutanea tarda
  • Other possible benefits include the reduction in risk of colonic cancer, macular degeneration and cataract formation, with improved dentition and skin healing – these are still controversial and not seen as indications

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